AACR 101st Annual Meeting 2010 April 17, 2010

Scott Hammond, Senior Scientist will present a poster on metastatic colorectal cancer cells.

Haihong (Helen) Zhong, Scientist II will present a poster on fully human anti-interleukin-6 monoclonal antibody suppresses the growth of human tumor xenograft in vivo.

Ivan Inigo, Associate Scientist will present a poster on the combination of MEDI3617, a fully human anti-angiopoietin z monoclonal antibody, with inhibitors of the VEGF pathway enhances antitumor activity in vivo.

Jiagi Huang, Principal Scientist will present a poster on the molecular characterization of circulating tumor cells using fluidigm biomark dynamic array.

Stacy Fuhrmann, Associate Scientist I will present a poster on in vitro and in vivo pharmacology of MEDI565, a novel CEA/CD3 - bispecific single-chain antibody for the treatment of gastrointestinal adenocarcinomas.

Dowdy Jackson, Scientist II will present a poster on EphA2-targeting antibody-gelonin conjugate specifically binds and kills target-expressing tumor cells, including multi-drug resistant (MDR) lines.

Abstract by Li Peng, Scientist 1, Oberst, Huang, Brohawn, et. Al. will be presented on the CEA/CD3-bispecific antibody MEDI565 (MT111) binds a nonlinear epitope present in the full-length but not a short splice variant of CEA.